Simply Health ME E39 – Brain Health

Brain Health

Depression and other psychiatric disorder (Rhonda Patrick)

Acute inflammation may be an antidepressant

Chronic inflammation may cause depression


The Knockout Project

Dementia / Parkinsons

Type 3 diabetes

IF and Ketones help

Mattson(see reference) at Hopkins  and his colleagues have found that intermittent fasting—limiting caloric intake at least two days a week—can help improve neural connections in the hippocampus while protecting neurons against the accumulation of amyloid plaques, a protein prevalent in people with Alzheimer’s disease. “Fasting is a challenge to your brain, and we think that your brain reacts by activating adaptive stress responses that help it cope with disease,” says Mattson. “From an evolutionary perspective, it makes sense your brain should be functioning well when you haven’t been able to obtain food for a while.

He explains that every time you eat, glucose is stored in your liver as glycogen, which takes about 10 to 12 hours to be depleted. After the glycogen is used up, your body starts burning fats, which are converted to ketone bodies, acidic chemicals used by neurons as energy. Ketones promote positive changes in the structure of synapses important for learning, memory, and overall brain health.

Ketogenic Diets

  • Ketones are preferred source of fuel in brain
  • Dementia considered type 3 diabetes (brain is unable to use glucose well)
  • Essentially starving. Needs a different kind of fuel
  • Check out work by Dr. Perlmutter (neurologist)
  • Used in epilepsy, neurodegenerative disorders.
  • My help by a similar mechanism in ASD, ADHD, schizophrenia
  • May be related to mitochondria
  • May be related to sleep


But eating a better diet – you have nothing to lose (except some pounds)

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