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Mini series on hormones.
Thanks to our new Patreon supporter “Drew from Liverpool, England!”.
Asked about dopamine and other hormones. We will get there!
Inverse correlation between measures of obesity and testosterone levels.
The larger the waist the lower your testosterone
Prevalence in men with type 2 diabetes is 40%
Insulin resistance, increase fat mass, high cholesterol, high blood pressure, increase risk, diabetes, of heart attack
Independent risk factor for ALL cause mortality
Symptoms of low testosterone
- low libido,
- hair loss,
- low muscle mass etc.
Obesity causes low testosterone because testosterone is converted to estradiol (an estrogen) by aromatase enzymes in fat cells. More estrogen causes feminization of men. ‘Moobs’. Decreased fertility
Then reduced testosterone increases adipocyte (fat cells) (vicious cycle) and decreases lean mass (worsening body composition)
Testosterone also works on something called the hypothalamic-pituitary-testicular axis. This hormone “highway” connects your brain to your reproductive organs. Obesity acts on this highway to reduce testosterone
What to Do
- Weight loss from diet, exercise, bariatric surgery sig increase testosterone levels
- Increase in testosterone is proportional to weight loss
Testosterone replacement (or increasing your own)
- Increase lean body mass
- Decrease fat mass and body fat
- Decreases waist circumference
- Increase lipolysis
- Decrease inflammatory markers
- Decreases triglycerides and increase HDL, decreases ApoB
- BUT some possible safety risk with exogenous replacement